This CTSA application from Washington University in St. Louis (WU) is built on a long institutional history of outstanding biomedical research, research training, and patient care. WU is the recipient of the 4 clinical research and training grants that form the basis of the CTSA (GCRC, currently in its 46th year of funding, and K12, K30, and T32 grants.) Another critical element is WU's new BioMed 21 strategic initiative in multidisciplinary, collaborative research in genome sciences, biological imaging, and clinical investigation. All these elements will be conjoined with other existing resources at WU to form a transformational new Institute of Clinical and Translational Sciences (ICTS). By implementing the 15 key Program Functions described in this application, the ICTS will conceptually and operationally reinvent and reinvigorate clinical and translational research and clinical research training at WU. An unprecedented level of partnership with other academic, healthcare, community and scientific institutions that complement our core expertise in laboratory and clinical research and research training is central to the transformation that will be led by the ICTS. Our partners include BJC HealthCare, an integrated academic and community health care delivery system;Saint Louis University School of Public Health, Graduate School and Doisy College of Health Sciences;University of Missouri St. Louis College of Nursing;Southern Illinois University Edwardsville School of Nursing;and St. Louis College of Pharmacy;key organizations promoting community health as well as biomedical and pharmaceutical companies in the St. Louis area. The coupling of these resources creates an outstanding environment to make basic laboratory discoveries that can then be translated into clinical research protocols and ultimately into advances in clinical practice and patient care through extensive community interactions and commercial partnerships."""""""" To ensure the success of the ICTS, WU has made substantial commitments of space and financial support. Barnes-Jewish and St. Louis Children?s Hospitals, our academic hospital-partners, and-BJC HealthCare, our affiliated health system, have also made substantial commitments to the clinical research activities of the ICTS. These additional resources coupled with the existing high quality programs in clinical and translational science ensure that WU will make outstanding contributions to this NIH initiative.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-1 (02))
Program Officer
Sawczuk, Andrea
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
Zip Code
Kolinsky, Daniel C; Liang, Stephen Y (2018) Musculoskeletal Infections in the Emergency Department. Emerg Med Clin North Am 36:751-766
Charshafian, Stephanie; Liang, Stephen Y (2018) Rapid Fire: Infectious Disease Emergencies in Patients with Cancer. Emerg Med Clin North Am 36:493-516
Liang, Stephen Y; Riethman, Madison; Fox, Josephine (2018) Infection Prevention for the Emergency Department: Out of Reach or Standard of Care? Emerg Med Clin North Am 36:873-887
Dad, Taimur; Abebe, Kaleab Z; Bae, K Ty et al. (2018) Longitudinal Assessment of Left Ventricular Mass in Autosomal Dominant Polycystic Kidney Disease. Kidney Int Rep 3:619-624
Nicol, Ginger E; Yingling, Michael D; Flavin, Karen S et al. (2018) Metabolic Effects of Antipsychotics on Adiposity and Insulin Sensitivity in Youths: A Randomized Clinical Trial. JAMA Psychiatry 75:788-796
Yoshino, Jun; Almeda-Valdes, Paloma; Moseley, Anna C et al. (2018) Percutaneous muscle biopsy-induced tissue injury causes local endoplasmic reticulum stress. Physiol Rep 6:e13679
Kleinberger, Jeffrey W; Copeland, Kenneth C; Gandica, Rachelle G et al. (2018) Monogenic diabetes in overweight and obese youth diagnosed with type 2 diabetes: the TODAY clinical trial. Genet Med 20:583-590
Gonzalez, Kim L; Ratzel, Sarah E; Burks, Kendall H et al. (2018) A pex1 missense mutation improves peroxisome function in a subset of Arabidopsis pex6 mutants without restoring PEX5 recycling. Proc Natl Acad Sci U S A 115:E3163-E3172
Chondronikola, Maria; Magkos, Faidon; Yoshino, Jun et al. (2018) Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Obesity (Silver Spring) 26:683-688
Falvo, Michael J; Rohrbaugh, John W; Alexander, Thomas et al. (2018) Effects of Parkinson disease and antiparkinson medication on central adaptations to repetitive grasping. Life Sci 200:1-5

Showing the most recent 10 out of 1312 publications