Protein phosphatases play a key role in controlling cell growth and proliferation. We have cloned cDNAs encoding four different PTPases and two isoforms of protein serine/threonine phosphatase 2C from mouse testis. The physiological role(s) of intracellular and receptor-linked transmembrane PTPases, their cellular protein substrates, the ligands of receptor-linked R-PTPases, and their functions in tumor suppression will be investigated.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES061046-05
Application #
5202236
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code