For FY09, the Integrated Research Facility in the Division of Clinical Research has significantly increased the level of research facilitation that it provides. Primarily, this support has been directed to facilitating the biodefense and emerging infectious disease research of the Emerging Viral Pathogens section in the Division of Intramural Research. Project 1: Viral pathogenesis of orthopoxviruses and development of countermeasures against infection: Introduction and Objectives 1) Characterize monkeypox virus infection of nonhuman primates by the intravenous and intrabronchial route. 2) Determine if cowpox virus infection of nonhuman primates could serve as a BSL-2 model of orthopoxvirus infection. 3) Determine the efficacy of mitoxantrone against cowpox virus in vivo. Project 2: Viral pathogenesis of simian hemorrhagic fever virus: Introduction and Objectives 1) To characterize the pathogenesis of simian hemorrhagic fever virus in nonhuman primates. Project 3: Identification of cell-surface receptors of viral entry: 1) Identification of cell-surface receptors for NIAID Priority Pathogens. 2) Identification of the cell-surface receptor of simian hemorrhagic fever virus. 3) Characterization of the role of filoviral secreted glycoproteins in filovirus cell entry. Project 4: Develop methods for medical imaging of infectious disease: 1) Development of tracers for orthopox viruses and filoviruses.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Zip Code
Bodas, Manish; Mazur, Steven; Min, Taehong et al. (2018) Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses. Respir Res 19:2
Cooper, Timothy K; Sword, Jennifer; Johnson, Joshua C et al. (2018) New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model. J Infect Dis :
Cline, John Mark; Dugan, Greg; Bourland, John Daniel et al. (2018) Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation. Antioxidants (Basel) 7:
Logue, James; Tuznik, Kaylie; Follmann, Dean et al. (2018) Use of the Filovirus Animal Non-Clinical Group (FANG) Ebola virus immuno-assay requires fewer study participants to power a study than the Alpha Diagnostic International assay. J Virol Methods 255:84-90
Rimoin, Anne W; Lu, Kai; Bramble, Matthew S et al. (2018) Ebola Virus Neutralizing Antibodies Detectable in Survivors of theYambuku, Zaire Outbreak 40 Years after Infection. J Infect Dis 217:223-231
Smith, Darci R; Johnston, Sara C; Piper, Ashley et al. (2018) Attenuation and efficacy of live-attenuated Rift Valley fever virus vaccine candidates in non-human primates. PLoS Negl Trop Dis 12:e0006474
Cooper, Timothy K; Huzella, Louis; Johnson, Joshua C et al. (2018) Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model. Sci Rep 8:1250
Dokubo, Emily Kainne; Wendland, Annika; Mate, Suzanne E et al. (2018) Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report. Lancet Infect Dis 18:1015-1024
Shantha, Jessica G; Mattia, John G; Goba, Augustine et al. (2018) Ebola Virus Persistence in Ocular Tissues and Fluids (EVICT) Study: Reverse Transcription-Polymerase Chain Reaction and Cataract Surgery Outcomes of Ebola Survivors in Sierra Leone. EBioMedicine 30:217-224
Jensen, Kenneth S; Adams, Ricky; Bennett, Richard S et al. (2018) Development of a novel real-time polymerase chain reaction assay for the quantitative detection of Nipah virus replicative viral RNA. PLoS One 13:e0199534

Showing the most recent 10 out of 85 publications