Abstract

For FY14, the Integrated Research Facility in the Division of Clinical Research has significantly increased the level of research facilitation that it provides. Primarily, this support has been directed to facilitating the biodefense and emerging infectious disease research of the Emerging Viral Pathogens section in the Division of Intramural Research, reported separately. In addition, core capabilities of the IRF have been established to include clinical pathology, anatomic pathology, electron microscopy, confocal microscopy, immunology, and cell culture. Rodents were introduced into the facility in November 2012, followed by primates in December of the same year. Medical imaging using all four modalities on uninfected animals was initiated in January 2013 followed by infections of non-Select Agents in March 2013. Aerosol infectivity studies began in April 2013, followed by influenza and MERS in July 2013. Research involving Ebola virus including West African strains was initiated in August 2014.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Support Services Intramural Research (ZID)
Project #
1ZIDAI009006-06
Application #
8946625
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Cooper, Timothy K; Huzella, Louis; Johnson, Joshua C et al. (2018) Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model. Sci Rep 8:1250
Dokubo, Emily Kainne; Wendland, Annika; Mate, Suzanne E et al. (2018) Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report. Lancet Infect Dis 18:1015-1024
Shantha, Jessica G; Mattia, John G; Goba, Augustine et al. (2018) Ebola Virus Persistence in Ocular Tissues and Fluids (EVICT) Study: Reverse Transcription-Polymerase Chain Reaction and Cataract Surgery Outcomes of Ebola Survivors in Sierra Leone. EBioMedicine 30:217-224
Jensen, Kenneth S; Adams, Ricky; Bennett, Richard S et al. (2018) Development of a novel real-time polymerase chain reaction assay for the quantitative detection of Nipah virus replicative viral RNA. PLoS One 13:e0199534
Tamhankar, Manasi; Gerhardt, Dawn M; Bennett, Richard S et al. (2018) Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells. Virol J 15:135
DeWald, Lisa Evans; Dyall, Julie; Sword, Jennifer M et al. (2018) The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease. J Infect Dis :
Ward-Kavanagh, Lindsay K; Kokolus, Kathleen M; Cooper, Timothy K et al. (2018) Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors. Cancer Immunol Immunother 67:639-652
Cong, Yu; Hart, Brit J; Gross, Robin et al. (2018) MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells. PLoS One 13:e0194868
Pleet, Michelle L; Erickson, James; DeMarino, Catherine et al. (2018) Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles. J Infect Dis :
Postnikova, Elena; Cong, Yu; DeWald, Lisa Evans et al. (2018) Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs. PLoS One 13:e0194880

Showing the most recent 10 out of 85 publications