For FY14, the Integrated Research Facility in the Division of Clinical Research has significantly increased the level of research facilitation that it provides. Primarily, this support has been directed to facilitating the biodefense and emerging infectious disease research of the Emerging Viral Pathogens section in the Division of Intramural Research, reported separately. In addition, core capabilities of the IRF have been established to include clinical pathology, anatomic pathology, electron microscopy, confocal microscopy, immunology, and cell culture. Rodents were introduced into the facility in November 2012, followed by primates in December of the same year. Medical imaging using all four modalities on uninfected animals was initiated in January 2013 followed by infections of non-Select Agents in March 2013. Aerosol infectivity studies began in April 2013, followed by influenza and MERS in July 2013. Research involving Ebola virus including West African strains was initiated in August 2014.

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6
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2014
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Tamhankar, Manasi; Gerhardt, Dawn M; Bennett, Richard S et al. (2018) Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells. Virol J 15:135
DeWald, Lisa Evans; Dyall, Julie; Sword, Jennifer M et al. (2018) The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease. J Infect Dis :
Ward-Kavanagh, Lindsay K; Kokolus, Kathleen M; Cooper, Timothy K et al. (2018) Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors. Cancer Immunol Immunother 67:639-652
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Postnikova, Elena; Cong, Yu; DeWald, Lisa Evans et al. (2018) Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs. PLoS One 13:e0194880
Dyall, Julie; Johnson, Joshua C; Hart, Brit J et al. (2018) In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus. J Infect Dis :
Dyall, Julie; Nelson, Elizabeth A; DeWald, Lisa Evans et al. (2018) Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures. J Infect Dis :
Bramble, Matthew S; Hoff, Nicole; Gilchuk, Pavlo et al. (2018) Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors. J Infect Dis 218:1929-1936
Luke, Thomas; Bennett, Richard S; Gerhardt, Dawn M et al. (2018) Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate. J Infect Dis :

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