Abstract

In FY17, the Integrated Research Facility in the Division of Clinical Research has continued to provide research facilitation through core capabilities that include clinical pathology, anatomic pathology, electron microscopy, confocal microscopy, immunology, and cell culture. Support was provided primarily to a large number of academic and industrial collaborators as well as to the Emerging Viral Pathogens section in the Division of Intramural Research (DIR) to facilitate discovery of medical countermeasures and improve diagnostics for emerging infectious diseases and biodefense pathogens. This facilitation was concentrated primarily on orthopoxviruses, Ebola, Marburg, Nipah, Influenza, and Lassa viruses, in addition to MERS CoV.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Support Services Intramural Research (ZID)
Project #
1ZIDAI009006-09
Application #
9568297
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Cooper, Timothy K; Sword, Jennifer; Johnson, Joshua C et al. (2018) New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model. J Infect Dis :
Cline, John Mark; Dugan, Greg; Bourland, John Daniel et al. (2018) Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation. Antioxidants (Basel) 7:
Logue, James; Tuznik, Kaylie; Follmann, Dean et al. (2018) Use of the Filovirus Animal Non-Clinical Group (FANG) Ebola virus immuno-assay requires fewer study participants to power a study than the Alpha Diagnostic International assay. J Virol Methods 255:84-90
Rimoin, Anne W; Lu, Kai; Bramble, Matthew S et al. (2018) Ebola Virus Neutralizing Antibodies Detectable in Survivors of theYambuku, Zaire Outbreak 40 Years after Infection. J Infect Dis 217:223-231
Smith, Darci R; Johnston, Sara C; Piper, Ashley et al. (2018) Attenuation and efficacy of live-attenuated Rift Valley fever virus vaccine candidates in non-human primates. PLoS Negl Trop Dis 12:e0006474
Cooper, Timothy K; Huzella, Louis; Johnson, Joshua C et al. (2018) Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model. Sci Rep 8:1250
Dokubo, Emily Kainne; Wendland, Annika; Mate, Suzanne E et al. (2018) Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report. Lancet Infect Dis 18:1015-1024
Shantha, Jessica G; Mattia, John G; Goba, Augustine et al. (2018) Ebola Virus Persistence in Ocular Tissues and Fluids (EVICT) Study: Reverse Transcription-Polymerase Chain Reaction and Cataract Surgery Outcomes of Ebola Survivors in Sierra Leone. EBioMedicine 30:217-224
Jensen, Kenneth S; Adams, Ricky; Bennett, Richard S et al. (2018) Development of a novel real-time polymerase chain reaction assay for the quantitative detection of Nipah virus replicative viral RNA. PLoS One 13:e0199534
Tamhankar, Manasi; Gerhardt, Dawn M; Bennett, Richard S et al. (2018) Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells. Virol J 15:135

Showing the most recent 10 out of 85 publications