Abstract

In FY16, the Integrated Research Facility in the Division of Clinical Research has continued to provide research facilitation through core capabilities that include clinical pathology, anatomic pathology, electron microscopy, confocal microscopy, immunology, and cell culture. Support was provided primarily to a large number of academic and industrial collaborators as well as to the Emerging Viral Pathogens section in the Division of Intramural Research (DIR) to facilitate discovery of medical countermeasures and improve diagnostics for emerging infectious diseases and biodefense pathogens. This facilitation was concentrated primarily on orthopoxviruses, Ebola, Marburg, Nipah, Influenza, and Lassa viruses, in addition to MERS CoV.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Support Services Intramural Research (ZID)
Project #
1ZIDAI009006-08
Application #
9354140
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Bramble, Matthew S; Hoff, Nicole; Gilchuk, Pavlo et al. (2018) Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors. J Infect Dis 218:1929-1936
Luke, Thomas; Bennett, Richard S; Gerhardt, Dawn M et al. (2018) Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate. J Infect Dis :
Davey Jr, Richard T; Dodd, Lori; Proschan, Michael et al. (2018) The Past Need Not Be Prologue: Recommendations for Testing and Positioning the Most-Promising Medical Countermeasures for the Next Outbreak of Ebola Virus Infection. J Infect Dis :
Iwasaki, Masaharu; Minder, Petra; Caì, Yíngyún et al. (2018) Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses. PLoS Pathog 14:e1006892
Bodas, Manish; Mazur, Steven; Min, Taehong et al. (2018) Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses. Respir Res 19:2
Cooper, Timothy K; Sword, Jennifer; Johnson, Joshua C et al. (2018) New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model. J Infect Dis :
Cline, John Mark; Dugan, Greg; Bourland, John Daniel et al. (2018) Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation. Antioxidants (Basel) 7:
Logue, James; Tuznik, Kaylie; Follmann, Dean et al. (2018) Use of the Filovirus Animal Non-Clinical Group (FANG) Ebola virus immuno-assay requires fewer study participants to power a study than the Alpha Diagnostic International assay. J Virol Methods 255:84-90
Rimoin, Anne W; Lu, Kai; Bramble, Matthew S et al. (2018) Ebola Virus Neutralizing Antibodies Detectable in Survivors of theYambuku, Zaire Outbreak 40 Years after Infection. J Infect Dis 217:223-231
Smith, Darci R; Johnston, Sara C; Piper, Ashley et al. (2018) Attenuation and efficacy of live-attenuated Rift Valley fever virus vaccine candidates in non-human primates. PLoS Negl Trop Dis 12:e0006474

Showing the most recent 10 out of 85 publications