The Investigator requests three additional years of funding to investigate how oropharyngeal and postingestional food-related stimulation interact and influence behavior. Previous work by the Investigator has revealed that the initial rate of licking of a test solution is a linear function of the log concentration of a variety of different carbohydrates and oils. The rate of decline of the rate of licking is a linear increasing function of the log of carbohydrate concentration and an exponential increasing function of the log concentration of corn oil. It is the combination of these two effects on the licking behavior of the rat, one acting at the oropharyngeal level and the other at the post-ingestive level, that determines how much will be ingested in a short-term test; i.e., a meal. All of these parameters can best be determined by investigation of the microstructure of licking; i.e., by analyzing the size of bursts of licking, and the pauses between bursts have been shown to be highly correlated with these. The Investigator now proposes to determine the role of various branches of the vagus in conveying information pertinent to this behavior to the CNS; the nature of specifically gastric stimulation in controlling meal size; the basis for conditioned control of the overall intake; and the properties of certain oils that alter responding.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041563-09
Application #
2414800
Study Section
Biopsychology Study Section (BPO)
Project Start
1990-05-01
Project End
1999-04-30
Budget Start
1997-05-01
Budget End
1998-04-30
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Davis, John D; Smith, Gerard P; McCann, D P (2002) The control of water and sodium chloride intake by postingestional and orosensory stimulation in water-deprived rats. Physiol Behav 75:7-14
Davis, J D; Smith, G P; Singh, B et al. (2001) The impact of sucrose-derived unconditioned and conditioned negative feedback on the microstructure of ingestive behavior. Physiol Behav 72:393-402
Kochavi, D; Davis, J D; Smith, G P (2001) Corticotropin-releasing factor decreases meal size by decreasing cluster number in Koletsky (LA/N) rats with and without a null mutation of the leptin receptor. Physiol Behav 74:645-51
Davis, J D; Smith, G P; Singh, B et al. (2000) The impact of milk-derived unconditioned and conditioned negative feedback on the microstructure of ingestive behavior. Physiol Behav 70:279-85
Davis, J D; Smith, G P; Singh, B (2000) Type of negative feedback controlling sucrose ingestion depends on sucrose concentration. Am J Physiol Regul Integr Comp Physiol 278:R383-9
Davis, J D; Breslin, P A (2000) A behavioral analysis of the ingestion of glucose, maltose and maltooligosaccharide by rats. Physiol Behav 69:477-85
Davis, J D; Smith, G P; Singh, B et al. (1999) Increase in intake with sham feeding experience is concentration dependent. Am J Physiol 277:R565-71
Davis, J D; Smith, G P; Singh, B (1999) A microstructural analysis of the control of water and isotonic saline ingestion by postingestional stimulation. Physiol Behav 66:543-8
Davis, J D (1999) Some new developments in the understanding of oropharyngeal and postingestional controls of meal size. Nutrition 15:32-9
Davis, J D; Smith, G P; Sayler, J L (1997) Reduction of intake in the rat due to gastric filling. Am J Physiol 272:R1599-605

Showing the most recent 10 out of 22 publications