The most commonly used measure of ingestion is the volume consumed in a fixed period of time. It is clear that this measure is inadequate if one is interested in the reason a particular amount is ingested since this amount is determined by a variety of variables. A better understanding of how these variables determine consumption can be achieved by studying the individual behavioral components, the microstructure of ingestion. The goal of the research proposed here is to understand how some of the variables know to affect the amount ingested affect individual components of the behavior that constitute an ingestive episode. This information should provide better insights concerning the nature of the central organization of ingestive behavior than can be achieved by simply measuring amount ingested. The effects of adulteration of sucrose solutions by quinine and citric acid, the dilution of sucrose and the effects of food and water deprivation on the microstructure will be studied. The changes in the microstructure of ingestive behavior of rats ingesting sucrose following the development of a conditioned taste aversion using four different US's will be measured. The sham feeding techniques is assumed to open the major negative feedback in the ingestive control system yet intake increases with experience in sham feeding suggesting the existence of an additional labile feedback loop. Experiments are planned to determine the reasons for this progressive increase and to study the microstructural changes that accompany it. The microstructural changes that accompany decreased intake induced by cholecystokinin and bombesin will be measured in sham feeding rats and these changes will be compared to those changes induced by the treatments described above in an attempt to understand the reasons for the anorectic properties of these peptides. This research will provide basic information about the microstructural changes in ingestive behavior induced by experimental alterations in volumetric intake. Since human ingestive behavior has some of the sam microstructural features which have been demonstrated in the rat the information provided by this research program should help to provide a better understanding of the nature of the various types of anorexias induced experimentally by drugs and occurring naturally in the form of anorexia nervosa.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041563-03
Application #
3242362
Study Section
Biopsychology Study Section (BPO)
Project Start
1990-05-01
Project End
1993-04-30
Budget Start
1992-06-01
Budget End
1993-04-30
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Type
Schools of Arts and Sciences
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612
Davis, John D; Smith, Gerard P; McCann, D P (2002) The control of water and sodium chloride intake by postingestional and orosensory stimulation in water-deprived rats. Physiol Behav 75:7-14
Davis, J D; Smith, G P; Singh, B et al. (2001) The impact of sucrose-derived unconditioned and conditioned negative feedback on the microstructure of ingestive behavior. Physiol Behav 72:393-402
Kochavi, D; Davis, J D; Smith, G P (2001) Corticotropin-releasing factor decreases meal size by decreasing cluster number in Koletsky (LA/N) rats with and without a null mutation of the leptin receptor. Physiol Behav 74:645-51
Davis, J D; Smith, G P; Singh, B et al. (2000) The impact of milk-derived unconditioned and conditioned negative feedback on the microstructure of ingestive behavior. Physiol Behav 70:279-85
Davis, J D; Smith, G P; Singh, B (2000) Type of negative feedback controlling sucrose ingestion depends on sucrose concentration. Am J Physiol Regul Integr Comp Physiol 278:R383-9
Davis, J D; Breslin, P A (2000) A behavioral analysis of the ingestion of glucose, maltose and maltooligosaccharide by rats. Physiol Behav 69:477-85
Davis, J D; Smith, G P; Singh, B et al. (1999) Increase in intake with sham feeding experience is concentration dependent. Am J Physiol 277:R565-71
Davis, J D; Smith, G P; Singh, B (1999) A microstructural analysis of the control of water and isotonic saline ingestion by postingestional stimulation. Physiol Behav 66:543-8
Davis, J D (1999) Some new developments in the understanding of oropharyngeal and postingestional controls of meal size. Nutrition 15:32-9
Davis, J D; Smith, G P; Sayler, J L (1997) Reduction of intake in the rat due to gastric filling. Am J Physiol 272:R1599-605

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